DreamWorks Animation’s newest installment is called “Monsters vs. Aliens” and they have cast some big-time stars to provide the vocal talents.

Reese Witherspoon, Hugh Laurie, Will Arnett, Stephen Colbert, Seth Rogen, Rainn Wilson, Kiefer Sutherland and Paul Rudd will all be part of “Monsters vs. Aliens,” produced in Ultimate 3-D technology.

Variety magazine said this of the “Monsters vs. Aliens” plot:

“Story, which reinvents the classic ’50s monster movie as a modern-day action comedy, centers on California girl Susan Murphy (Witherspoon), who is unexpectedly clobbered by a meteor full of outer space gunk and mysteriously grows to 50 feet tall. She is captured and held in a secret government compound. The world learns that the military has been quietly rounding up other monsters over the years, including the brilliant but insect-headed Dr. Cockroach, Ph.D. (Laurie) and the macho half-ape, half-fish the Missing Link (Arnett).”

The rest of the cast goes like this:

• Seth Rogen plays B.O.B., an indestructible goo (think the Blob)
• Stephen Colbert plays the president of the United States
• Rainn Wilson, as evil alien Gallaxhar
• Kiefer Sutherland plays General W.R. Monger
• Paul Rudd as Susan’s fiancé, Derek

Sadly, we’ve got a bit of a wait for this — “Monsters vs. Aliens” is expected to be released in March 2009.